Counties entirely or partially within the district are Alachua, Baker, Bradford, Brevard, Clay, Duval, Flagler, Indian River, Lake, Marion, Nassau, Okeechobee, Orange, Osceola, Putnam, St. Johns, Seminole and Volusia.
The district operates and maintains more than 100 major and minor water control structures, including 11 spillways, three navigational locks, and approximately 300 miles of levees and canals.
The district owns or manages about 774,831 acres of land (through transfers, donations, fee-simple purchases and less-than-fee acquisitions). The majority of the property is open for the public to enjoy.